中美(河南)荷美尔肿瘤研究院

Ki won lee 教授

发布时间:2022-08-29
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Ki won lee,男,教授,硕士生导师。

研究方向:肿瘤化学预防

通讯地址:郑州市金水区东明路127号中美(河南)荷美尔肿瘤研究院

邮编:450001 

学习与工作经历:

2000.7 韩国首尔大学 食品生物技术专业 博士研究生、博士学位。自2020年至今任中美(河南)荷美尔肿瘤研究院教授。

研究方向与特色:

多年来一直从事与肿瘤发生及预防相关的信号转导通路的研究工作,主要研究肿瘤驱动基因诱导的信号转导途径及其在肿瘤细胞转化、癌变和癌症预防过程中作用,并得到韩国国家研究基金会的资助。 

近年承担的主要科研项目:

1. 韩国国家研究基金会,紫外光固化涂料在无氧环境中的固化转化率的应用研究NRF-2018R1D1A1B07042569,2018/01-2022/12,200万元,在研,主持

近年发表的SCI科研论文:

1. Oh SS, Lee KW, Madhi H, Jeong JW, Park S, Kim M, Lee Y, Han HT, Hwangbo C, Yoo J, Kim KD. Cordycepin Resensitizes T24R2 Cisplatin-Resistant Human Bladder Cancer Cells to Cisplatin by Inactivating Ets-1 Dependent MDR1 Transcription. Int J Mol Sci. 2020 Mar 2;21(5):1710. 

2. Yang H, Kang MJ, Hur G, Lee TK, Park IS, Seo SG, Yu JG, Song YS, Park JHY, Lee KW. Sulforaphene Suppresses Adipocyte Differentiation via Induction of Post-Translational Degradation of CCAAT/Enhancer Binding Protein Beta (C/EBPβ). Nutrients. 2020 Mar 13;12(3):758. 

3. Lee JY, Yang H, Lee TK, Lee CH, Seo JW, Kim JE, Kim SY, Park JHY, Lee KW. A short-term, hydroponic-culture of ginseng results in a significant increase in the anti-oxidative activity and bioactive components. Food Sci Biotechnol. 2020 Mar 7;29(7):1007-1012. 

4. Jeong M, Kim JH, Lee JS, Kang SD, Shim S, Jung MY, Yang H, Byun S, Lee KW. Heat-Killed Lactobacillus brevis Enhances Phagocytic Activity and Generates Immune-Stimulatory Effects through Activating the TAK1 Pathway. J Microbiol Biotechnol. 2020 Sep 28;30(9):1395-1403. 

5. Oh Y, Hwang HJ, Yang H, Kim JH, Park JHY, Kim JE, Lee KW. Orobol, A Derivative of Genistein, Inhibits Heat-Killed Propionibacterium acnes-Induced Inflammation in HaCaT Keratinocytes. J Microbiol Biotechnol. 2020 Sep 28;30(9):1379-1386. 

6. Lee Y , Yang H , Hur G , Yu J , Park S , Kim JH , Yoon Park JH , Shin HS , Kim JE , Lee KW . 5-(3',4'-Dihydroxyphenyl)-γ-valerolactone, a metabolite of procyanidins in cacao, suppresses MDI-induced adipogenesis by regulating cell cycle progression through direct inhibition of CDK2/cyclin O. Food Funct. 2019 May 22;10(5):2958-2969. 

7. Jeong M, Kim JH, Yang H, Kang SD, Song S, Lee D, Lee JS, Yoon Park JH, Byun S, Lee KW. Heat-Killed Lactobacillus plantarum KCTC 13314BP Enhances Phagocytic Activity and Immunomodulatory Effects Via Activation of MAPK and STAT3 Pathways. J Microbiol Biotechnol. 2019 Aug 28;29(8):1248-1254. 

8. Kim JS, Kim JH, Palaniyandi SA, Lee CC, You JW, Yang H, Yoon Park JH, Yang SH, Lee KW. Yak-Kong Soybean (Glycine max) Fermented by a Novel Pediococcus pentosaceus Inhibits the Oxidative Stress-Induced Monocyte-Endothelial Cell Adhesion. Nutrients. 2019 Jun 19;11(6):1380.